Pharyngula::More Mighty Mouse pictures

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Friday, June 25, 2004

More Mighty Mouse pictures

PZ Myers • 6 Comments

I got a request for a few more pictures of the muscle-bound mouse from the McPherron et al. paper, so here they are. The topmost picture in each pair is of a wild-type mouse, while the one below it is the myostatin mutant.

The hindlimb:

Pecs:

McPherron AC, Lawler AM, Lee SJ (1997) Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member. Nature 387(6628):83-90.

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Comments:

#3998: — 06/30 at 04:00 PM
Incredible pictures!
If you have more, then please send me some. I am especially interested in the belgian blue cattles.

Sincerely

Peter

#5662: — 08/31 at 03:08 AM
this myosatin... is it some kind of steroid?

#5663: PZ Myers — 08/31 at 05:44 AM
No, it's a regulatory protein.

PZ Myers
Division of Science and Math
University of Minnesota, Morris

#5675: — 08/31 at 04:26 PM
so it's something normally found in the body? then what the heck happened to the second rat?

#5676: PZ Myers — 08/31 at 05:25 PM
Myostatin is a negative regulator of muscle growth. It acts as a brake or governor, making sure that only as much muscle as you actually need and use develops. The mutant mouse has had its myostatin gene damaged so that it is nonfunctional, so it's like cutting the brake lines—muscle growth is out of control, and proceeds at a relatively unregulated rate.

PZ Myers
Division of Science and Math
University of Minnesota, Morris

#5684: — 09/01 at 03:19 AM
how fast did this muscle growth kick in? and what ended up happening to the rat... did it's muscles eventually grow too big for it's skin or what?

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Friday, June 25, 2004

More Mighty Mouse pictures

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